Takeda R, Sawa H, Sasaki M, Orba Y, Maishi N, Tsumita T, Ushijima N, Hida Y, Sano H, Kitagawa Y, Hida K. Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2. Sci Rep. 2022 Aug 18;12(1):14050. doi: 10.1038/s41598-022-18367-6. PMID: 35982118; PMCID: PMC9386671.
ABSTRACT
Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 µg/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations.
PDF: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386671/pdf/41598_2022_Article_18367.pdf
